Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury

Table 3 GO and KEGG pathways enrichment among predicted miRNAs and co-DEGs

Genes	Predicted miRNAs	Category		P value
SLPI	hsa-miR-370-3p	KEGG pathway	NA
	hsa-miR-3679-5p	GO terms	NA
	hsa-miR-520a-5p
TIMP1	hsa-miR-22-3p	KEGG pathway	HIF-1 signaling pathway	9e-05
	hsa-miR-4739	GO terms	regulation of integrin-mediated signaling pathway	0.002
	hsa-miR-1321		negative regulation of metalloenzyme activity	0.002
	hsa-miR-4756-5p		negative regulation of trophoblast cell migration	0.002
			negative regulation of membrane protein ectodomain proteolysis	0.002
			cell activation	0.005
			metalloendopeptidase inhibitor activity	0.005
			platelet alpha granule lumen	0.005
			platelet degranulation	0.008
			extracellular matrix disassembly	0.012
			response to peptide hormone	0.015
PTX3	hsa-miR-29a-3p	KEGG pathway	NA
	hsa-miR-29b-3p	GO terms	NA
	hsa-miR-29c-3p
	hsa-miR-101-3p
	hsa-miR-144-3p
VMP1	hsa-miR-19a-3p	KEGG pathway	MicroRNAs in cancer	3e-24
	hsa-miR-19b-3p		Proteoglycans in cancer	0.010
	hsa-miR-148a-3p	GO terms	autophagic vacuole membrane	0.008
	hsa-miR-152-3p		pre-autophagosomal structure	0.008
	miR-223-3p		cell junction assembly	0.008
			regulation of autophagy	0.008
			embryo implantation	0.009
			cell junction organization	0.014
			autophagy	0.017
			single organismal cell-cell adhesion	0.017

ISSN: 1601-5223