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Table 2 The GO terms enrichment for the co-DEGs of septic shock and AKI

From: Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury

Gene/product

GO class (direct)

Evidence

Reference

VMP1

protein binding

IPI

PMID:17724469

endoplasmic reticulum

IDA

GO_REF:0000052

autophagosome assembly

IMP

PMID:30093494

SLPI

protein binding

IPI

PMID:12526812

antibacterial humoral response

ISS

GO_REF:0000024

extracellular space

IDA

PMID:18714013

collagen-containing extracellular matrix

HDA

PMID:28675934

innate immune response

ISS

GO_REF:0000024

modulation of process of other organism

IDA

PMID:2467900

negative regulation of endopeptidase activity

IEA

GO_REF:0000108

serine-type endopeptidase inhibitor activity

IDA

PMID:3462719

PTX3

protein binding

IPI

PMID:19050261

complement component C1q complex binding

IDA

PMID:23544079

extracellular region

TAS

Reactome:R-HSA-6798745

extracellular space

IDA

PMID:23544079

innate immune response

IDA

PMID:23544079

TIMP1

protein binding

IPI

PMID:16917503

extracellular region

TAS

Reactome:R-HSA-1602454

metalloendopeptidase inhibitor activity

IDA

PMID:12714508

basement membrane

IEA

GO_REF:0000107

cytokine-mediated signaling pathway

TAS

Reactome:R-HSA-6783783

extracellular space

IDA

PMID:3903517

negative regulation of endopeptidase activity

IDA

PMID:3903517

negative regulation of membrane protein ectodomain proteolysis

IDA

PMID:12714508

OLFM4

protein binding

IPI

PMID:20534456

extracellular exosome

HDA

PMID:19056867

extracellular space

HDA

PMID:16502470

extracellular region

TAS

Reactome:R-HSA-6798745

plasma membrane

IDA

GO_REF:0000052

LCN2

protein binding

IPI

PMID:32296183

extracellular region

ISS

GO_REF:0000024

extracellular space

HDA

PMID:16502470

extracellular exosome

HDA

PMID:19056867

iron ion binding

ISS

GO_REF:0000024

S100A9

protein binding

IPI

PMID:17620599

extracellular region

TAS

PMID:22489132

collagen-containing extracellular matrix

HDA

PMID:23979707

extracellular space

HDA

PMID:16502470

cytosol

IDA

GO_REF:0000052

extracellular exosome

HDA

PMID:19056867

antimicrobial humoral immune response mediated by antimicrobial peptide

IDA

PMID:12874352

calcium ion binding

TAS

PMID:22489132

cytoplasm

IDA

PMID:12874352

leukocyte migration involved in inflammatory response

IDA

PMID:12626582

neutrophil aggregation

IDA

PMID:12626582

neutrophil chemotaxis

IDA

PMID:12626582

nucleus

HDA

PMID:21630459

  1. IPI physical interaction evidence used in manual assertion, IDA direct assay evidence used in manual assertion, ISS sequence similarity evidence used in manual assertion, IEA evidence used in automatic assertion, TAS traceable author statement used in manual assertion, IMP mutant phenotype evidence used in manual assertion, HAD high throughput direct assay evidence used in manual assertion