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Table 3 Associations between epistatic interactions and serum urate in subgroups of BMI and smoking status

From: Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout

SNP1SNP2 Subgroup-1Subgroup-2Subgroup-3
EstimateSEPintEstimateSEPintEstimateSEPint
rs2728121rs1481012BMI19.79441.8110.637−10.4838.3060.207−21.7029.4770.022
Smoke−25.46715.2100.095−7.75110.4780.460−9.1968.3430.271
rs2728121rs2231137BMI24.51222.9480.28811.4564.6200.0139.8444.9620.047
Smoke9.9728.3850.2357.1065.2230.1747.5924.6080.100
  1. SNP1 (SNP2), name of the first (second) SNP. SE, standard error. Pint, P-value of the interaction between the SNP pair in serum urate was calculated by linear regression adjusted age, gender and target SNPs. Subgroup of BMI: 1, Underweight (BMI < 18.5); 2, Normal (18.5 BMI < 25); 3, Overweight (BMI 25). Subgroup of smoke: 1, non-smokers; 2, former smokers; 3, current smokers