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Table 3 Associations between epistatic interactions and serum urate in subgroups of BMI and smoking status

From: Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout

SNP1

SNP2

 

Subgroup-1

Subgroup-2

Subgroup-3

Estimate

SE

Pint

Estimate

SE

Pint

Estimate

SE

Pint

rs2728121

rs1481012

BMI

19.794

41.811

0.637

−10.483

8.306

0.207

−21.702

9.477

0.022

Smoke

−25.467

15.210

0.095

−7.751

10.478

0.460

−9.196

8.343

0.271

rs2728121

rs2231137

BMI

24.512

22.948

0.288

11.456

4.620

0.013

9.844

4.962

0.047

Smoke

9.972

8.385

0.235

7.106

5.223

0.174

7.592

4.608

0.100

  1. SNP1 (SNP2), name of the first (second) SNP. SE, standard error. Pint, P-value of the interaction between the SNP pair in serum urate was calculated by linear regression adjusted age, gender and target SNPs. Subgroup of BMI: 1, Underweight (BMI < 18.5); 2, Normal (18.5 BMI < 25); 3, Overweight (BMI 25). Subgroup of smoke: 1, non-smokers; 2, former smokers; 3, current smokers