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Table 1 Associations between serum urate and epistatic interactions in PKD2 and ABCG2

From: Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout

Chr.SNP1Pos1A1SNP2Pos2A2DistLD (r2) EstimatePintVariance explained (%)
4rs272521588,961,571Trs148101289,039,082G77,5110.605Male−2.3090.693
Female−12.8170.236
Total−7.0200.181
4rs272521588,961,571Trs223113789,061,114T99,5430.116Male4.8300.618
Female20.1780.220
Total9.3060.270
4rs272812188,997,102Crs148101289,039,082G41,9800.370Male−6.0510.379
Female−33.3150.0060.493
Total−14.4870.0180.099
4rs272812188,997,102Crs223113789,061,114T64,0120.045Male8.9800.0170.144
Female9.2500.171
Total9.7810.0040.164
  1. Chr, chromosome of an SNP pair. SNP1 (SNP2), Pos1 (Pos2), name and position of the first (second) SNP. A1, effect allele of SNP1; A2, effect allele of SNP2. dist, distance in bp between two SNPs. LD (r2), linkage disequilibrium between two SNPs. Pint, P-value of the interaction between SNP pair in serum urate was calculated by linear regression adjusted age, gender, and target SNPs. Variance explained of the interaction between the SNP pair in serum urate was calculated by linear regression