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Table 1 Associations between serum urate and epistatic interactions in PKD2 and ABCG2

From: Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout

Chr.

SNP1

Pos1

A1

SNP2

Pos2

A2

Dist

LD (r2)

 

Estimate

Pint

Variance explained (%)

4

rs2725215

88,961,571

T

rs1481012

89,039,082

G

77,511

0.605

Male

−2.309

0.693

Female

−12.817

0.236

Total

−7.020

0.181

4

rs2725215

88,961,571

T

rs2231137

89,061,114

T

99,543

0.116

Male

4.830

0.618

Female

20.178

0.220

Total

9.306

0.270

4

rs2728121

88,997,102

C

rs1481012

89,039,082

G

41,980

0.370

Male

−6.051

0.379

Female

−33.315

0.006

0.493

Total

−14.487

0.018

0.099

4

rs2728121

88,997,102

C

rs2231137

89,061,114

T

64,012

0.045

Male

8.980

0.017

0.144

Female

9.250

0.171

Total

9.781

0.004

0.164

  1. Chr, chromosome of an SNP pair. SNP1 (SNP2), Pos1 (Pos2), name and position of the first (second) SNP. A1, effect allele of SNP1; A2, effect allele of SNP2. dist, distance in bp between two SNPs. LD (r2), linkage disequilibrium between two SNPs. Pint, P-value of the interaction between SNP pair in serum urate was calculated by linear regression adjusted age, gender, and target SNPs. Variance explained of the interaction between the SNP pair in serum urate was calculated by linear regression