Table 1 The names, abbreviations and main functions of the 13 hub genes
MCODE score. | Gene symbol | Full name | Function | EPC score |
|---|---|---|---|---|
23 | IFI27 | interferon alpha inducible protein 27 | May relate to pathways of Innate Immune System and Interferon gamma signaling. | 12.309 |
14 | IFITM1 | Interferon Induced Transmembrane Protein 1 | May relate to pathways of Class I MHC mediated antigen processing and presentation and B cell receptor signaling pathway | 6.575 |
12 | IFI44 | Interferon Induced Protein 44 | May participate the pathogenesis of Hepatitis D and Limited Scleroderma. | 6.469 |
12 | IFI44L | Interferon Induced Protein 44 Like | Diseases associated with IFI44L include Lymph Node Tuberculosis and Aicardi-Goutieres Syndrome. | 6.449 |
12 | LY6E | Lymphocyte Antigen 6 Family Member | Diseases associated with LY6E include T-Cell Lymphoma, Subcutaneous Panniculitis-Like and Acute Promyelocytic Leukemia | 6.394 |
11 | OASL | 2′-5′-Oligoadenylate Synthetase Like | May relate to pathways of Innate Immune System and PI3K-Akt signaling pathway. | 6.379 |
11 | IFI6 | Interferon Alpha Inducible Protein 6 | May play a critical role in the regulation of apoptosis | 6.343 |
11 | OAS1 | 2′-5′-Oligoadenylate Synthetase 1 | Activates latent RNase L resulting in viral RNA degradation and the inhibition of viral replication | 6.342 |
11 | ISG15 | ISG15 Ubiquitin Like Modifie | Chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections | 6.319 |
10 | RSAD2 | Radical S-Adenosyl Methionine Domain Containing 2 | Diseases associated with RSAD2 include Yellow Fever and Chikungunya | 6.312 |
10 | EIF2AK2 | Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2 | Diseases associated with EIF2AK2 include Herpes Simplex and Hepatitis C | 6.213 |
10 | PLSCR1 | Phospholipid Scramblase 1 | May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions | 6.193 |
10 | IFITM3 | Interferon Induced Transmembrane Protein 3 | Helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus | 6.141 |