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Fig. 1 | Hereditas

Fig. 1

From: Defining muscle-invasive bladder cancer immunotypes by introducing tumor mutation burden, CD8+ T cells, and molecular subtypes

Fig. 1

Classifying MIBC patients into three immunotypes. a The heat map shows the clinical features of the two molecular subtypes as well as the expression distribution of molecular subtype and immune-related biomarkers. b The Kaplan-Meier (K-M) plot indicates that MIBC samples with a high level of CD8+ T cells have a better overall survival profile than those with low CD8+ T cells. c The K-M plot indicates that MIBC samples with a high level of TMB have a better overall survival profile than those with low TMB. d Distribution of CD8+ T cells among the molecular subtype, age, gender, stage, grade, and primary therapy response groups in the TCGA dataset. e Distribution of TMB among the molecular subtype, age, gender, stage, grade, and primary therapy response groups in the TCGA dataset. f The graphic depicting the relative change in area under the CDF curve, which allows determining the optimal K of 3 by first “elbow” rule. g The consensus matrices with samples as both rows and columns, ranging from 0 (never clustered together) to 1 (always clustered together)

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