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Table 1 GO enrichment for the genes in the coexpression modules of HCM

From: Weighted gene co-expression network analysis revealed key biomarkers associated with the diagnosis of hypertrophic cardiomyopathy

 

Term

Count

Percentage%

p value

Module black

GO:0006614 ~ SRP-dependent cotranslational protein targeting to membrane

42

13.72549

2.17E-48

GO:0000184 ~ nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

43

14.05229

7.92E-45

GO:0003735 ~ structural constituent of ribosome

52

16.99345

1.92E-43

GO:0006413 ~ translation initiation

42

13.72549

2.32E-40

GO:0005840 ~ ribosome

44

14.37908

3.65E-40

Module blue

GO:0005829 ~ cytosol

154

38.11881

7.31E-23

GO:0044822 ~ poly(A) RNA binding

75

18.56436

3.88E-17

GO:0005515 ~ protein binding

273

67.57426

8.90E-15

GO:0005739 ~ mitochondrion

75

18.56436

2.61E-14

GO:0070062 ~ extracellular exosome

115

28.46535

3.13E-12

Module brown

GO:0005515 ~ protein binding

239

67.12483

4.32E-14

GO:0070062 ~ extracellular exosome

102

28.65169

1.69E-11

GO:0005829 ~ cytosol

112

31.46067

9.05E-11

GO:0005739 ~ mitochondrion

58

16.29213

3.13E-09

GO:0043209 ~ myelin sheath

16

4.494382

1.75E-07

Module green

GO:0006281 ~ DNA repair

9

4.945055

0.001606

GO:0005739 ~ mitochondrion

24

13.18681

0.001903

GO:0005743 ~ mitochondrial inner membrance

12

6.593407

0.002201

GO:1903146 ~ regulation of mitophagy

4

2.197802

0.003498

GO:0005515 ~ protein binding

101

55.49451

0.003597

Module pink

GO:0044822 ~ poly(A) RNA binding

24

24

1.27E-08

GO:0005515 ~ protein binding

70

70

5.93E-07

GO:0005829 ~ cytosol

36

36

4.25E-06

GO:0005654 ~ nucleoplasm

32

32

6.74E-06

GO:0003723 ~ RNA binding

13

13

2.91E-05

Module turquoise

GO:0070062 ~ extracellular exosome

237

28.31541

1.66E-24

GO:0005515 ~ protein binding

535

63.91876

6.94E-24

GO:0005829 ~ cytosol

259

30.94385

3.09E-22

GO:0044822 ~ poly(A) RNA binding

122

14.57587

2.18E-19

GO:0006412 ~ translation

49

5.854241

2.69E-17

Module yellow

GO:0070062 ~ extracellular exosome

125

36.54971

6.04E-23

GO:0031012 ~ extracellular matrix

40

11.69591

2.10E-22

GO:0005615 ~ extracellular space

59

17.25146

7.14E-10

GO:0005925 ~ focal adhesion

29

8.479532

8.16E-10

GO:0005576 ~ extracellular region

65

19.00585

2.04E-09

  1. Abbreviations: GO Gene Ontology, SRP signal recognition particle