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Fig. 3 | Hereditas

Fig. 3

From: Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage

Fig. 3

EDC4 overexpression reduced DNA damage caused by DDP and enhanced cell growth of cervical cancer cells. a The level of EDC4 in HeLa and SiHa cells after EDC4 overexpression analyzed by RT-PCR; b The expression of EDC4 in HeLa and SiHa cells after EDC4 overexpression analyzed by Western blot. c The cell viability of EDC4 overexpressed cells measured by MTT. d The cell growth of HeLa and SiHa (with EDC4 overexpression) after treated with DDP evaluated by colony formation assay. (E) The DNA damage of HeLa and SiHa (with EDC4 overexpression) analyzed by γH2AX immunofluorescent staining. *p < 0.05, **p < 0.01 vs. Vector; #p < 0.05, ##p < 0.01 vs. Vector + DDP

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Hereditas

ISSN: 1601-5223

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