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Fig. 4 | Hereditas

Fig. 4

From: Identification of MMP1 as a potential gene conferring erlotinib resistance in non-small cell lung cancer based on bioinformatics analyses

Fig. 4

Validation of MMP1 hub genes related to erlotinib resistance in NSCLC. a Proteins/genes interaction network of MMP1 created by GeneMANIA. The network legends refer to the interaction types (illustrated in the networks) between proteins/genes. b Relative mRNA level of 4 genes interacting with MMP1 based on the microarray data of GSE80344. c Representative immunohistochemistry staining of COPS5 expression in normal lung tissues and NSCLC tissues. d Positive correlation between MMP1 and COPS5 expression in the Tumor Lung (R = 0.236, P = 0.02). e The prognostic value was obtained from the GEPIA2 database when both MMP1 and COPS5 were highly expressed (HR = 1.7, P = 0.047)

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ISSN: 1601-5223

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