Table 5 Candidate drugs targeting hub genes

CXCR2

PROPOFOL

agonist

GuideToPharmacologyInteractions

–

CXCR2

BENZPIPERYLON

agonist

GuideToPharmacologyInteractions

–

CXCR2

CHEMBL411250

agonist

GuideToPharmacologyInteractions

–

CXCR2

MEPHENTERMINE

agonist

GuideToPharmacologyInteractions

–

CXCR2

REPARIXIN

allosteric modulator|modulator|antagonist

GuideToPharmacologyInteractions|ChemblInteractions|TTD

–

CXCR2

DANIRIXIN

antagonist

GuideToPharmacologyInteractions|ChemblInteractions

–

CXCR2

NAVARIXIN

antagonist

GuideToPharmacologyInteractions|ChemblInteractions|TTD

–

CXCR2

CHEMBL239767

antagonist

GuideToPharmacologyInteractions

–

CXCR2

NAVARIXIN HYDRATE

antagonist

ChemblInteractions

–

CXCR2

ELUBRIXIN

antagonist

ChemblInteractions|TTD

–

CXCR2

Ladarixin

modulator

ChemblInteractions

–

CXCR2

BEVACIZUMAB

–

PharmGKB

–

CXCR2

CYCLOPHOSPHAMIDE

–

PharmGKB

–

CXCR2

ACETYLCYSTEINE

–

NCI

10,716,998

CXCR2

MECHLORETHAMINE HYDROCHLORIDE

–

NCI

12,753,603

CXCR2

VITAMIN E

–

NCI

16,679,868

CXCR2

GENISTEIN

–

NCI

9,712,063

ISG15

IRINOTECAN

inhibitor

MyCancerGenomeClinicalTrial

–

OASL

PEGINTERFERON ALFA-2B

–

PharmGKB

–

OASL

RIBAVIRIN

–

PharmGKB

–

IVL

ETRETINATE

–

NCI

12,445,200|8,381,448

IVL

RETINYL ACETATE

–

NCI

6,189,593

IVL

PERILLYL ALCOHOL

–

NCI

10,769,631

CXCL10

NI-0801

inhibitor

ChemblInteractions

–

CXCL10

METHYLPREDNISOLONE

–

NCI

17,220,550

CXCL10

TESTOSTERONE

–

NCI

9,681,518

CXCL10

REGRAMOSTIM

–

NCI

11,591,765

CXCL10

OXALIPLATIN

–

NCI

16,101,140

CXCL10

ANTIBIOTIC

–

NCI

10,634,213

CXCL10

ZIDOVUDINE

–

NCI

11,141,242

CXCL10

ATROPINE

–

NCI

15,315,164

CXCL10

ELDELUMAB

–

TdgClinicalTrial

–

CXCL10

STAVUDINE

–

NCI

11,141,242

CXCL10

GONADOTROPIN, CHORIONIC

–

NCI

15,590,984

CXCL10

RITONAVIR

–

NCI

11,141,242

CXCL10

ATORVASTATIN

–

NCI

10,559,511