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Table 1 Top 10 GO terms in biological process for differentially expressed genes (DEGs) in gene expression profile of psoriatic patients (P < 0.05)

From: Identification of candidate biomarkers and pathways associated with psoriasis using bioinformatics analysis

ID

Name

Pvalue

DEGs

GO:0031424

Keratinization

6.15E-10

SPRR2C, SPRR1A, SPRR1B, LCE3D, TGM1, CNFN, SPRR3, TGM3, SPRR2G, IVL

GO:0030216

Keratinocyte differentiation

9.07E-10

SPRR2C, S100A7, SPRR1A, SPRR1B, LCE3D, TGM1, CNFN, SPRR3, TGM3, SPRR2G, IVL

GO:0009913

Epidermal cell differentiation

2.01E-09

SPRR2C, S100A7, SPRR1A, SPRR1B, LCE3D, TGM1, CNFN, SPRR3, TGM3, SPRR2G, IVL

GO:0007398

Ectoderm development

1.76E-08

KRT6A, S100A7, LCE3D, SPRR2G, SPRR2C, KRT16, SPRR1A, SPRR1B, CNFN, TGM1, SPRR3, TGM3, ALOX12B, IVL

GO:0030855

Epithelial cell differentiation

4.85E-08

RHCG, SPRR2C, S100A7, SPRR1A, SPRR1B, LCE3D, TGM1, CNFN, SPRR3, TGM3, SPRR2G, IVL

GO:0006952

Defense response

5.96E-08

CXCL1, DCD, KYNU, IL8, S100A8, S100A7, S100A9, CXCL9, RSAD2, CXCR2, CCL18, S100A12, CXCL10, WFDC12, FOS, CCL20, CXCL13, IRF7, LTF, MX1

GO:0008544

Epidermis development

7.87E-08

S100A7, LCE3D, SPRR2G, SPRR2C, SPRR1A, KRT16, SPRR1B, CNFN, TGM1, SPRR3, TGM3, ALOX12B, IVL

GO:0060429

Epithelium development

6.53E-07

S100A7, LCE3D, SPRR2G, GREM1, SPRR2C, RHCG, SPRR1A, SPRR1B, CNFN, TGM1, SPRR3, TGM3, IVL

GO:0006935

Chemotaxis

2.12E-06

CXCL1, IL8, CCL20, CXCL13, S100A9, CXCL9, CXCR2, CCL27, CCL18, CXCL10

GO:0042330

Taxis

2.12E-06

CXCL1, IL8, CCL20, CXCL13, S100A9, CXCL9, CXCR2, CCL27, CCL18, CXCL10