Fig. 3

3′-UTR of XBP1 was the direct target of miR-330-3p. a The putative binding sites between miR-330-3p and 3′-UTR of XBP1; b Luciferase activity was decreased in co-transfection of pGL3-XBP1-WT and miR-330-3p mimic but no change in co-transfection of pGL3-XBP1-MUT and miR-330-3p mimic; c miR-330-3p expression was increased by miR-330-3p mimic and decreased by miR-330-3p inhibitor; d Protein expression was reduce by miR-330-3p mimic and induced by miR-330-3p inhibitor. ** p < 0.01 vs. NC mimic or NC inh; *** p < 0.005 vs. NC mimic or NC inh