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Table 2 Total and stratified analysis of MTHFR rs1801131 A/C polymorphism and each urinary cancer variables

From: Association between methylenetetrahydrofolate reductase gene rs1801131 A/C polymorphism and urinary tumors’ susceptibility

VariablesNCase/ControlC-allele vs. A-alleleCA vs. AACC vs. CA + AACC + CA vs. AA
OR(95%CI) PhOR(95%CI) PhOR(95%CI) PhOR(95%CI) Ph
Total289110/121051.06(0.98–1.15)0.0001.12(1.01–1.24)0.0001.01(0.87–1.17)0.0211.09(1.00–1.19)0.003
HWE258747/116571.03(0.96–1.11)0.0011.11(1.00–1.24)0.0000.93(0.84–1.02)0.4321.06(0.98–1.16)0.006
Prostate cancer
 Total114419/65871.02(0.91–1.14)0.0160.99(0.91–1.07)0.5691.00(0.81–1.25)0.0620.99(0.91–1.07)0.253
 HWE94224/63110.96(0.91–1.02)0.6560.99(0.91–1.07)0.4230.90(0.79–1.04)0.9180.97(0.90–1.05)0.461
Ethnicity
 Caucasian83545/54531.02(0.88–1.17)0.0080.96(0.88–1.06)0.6220.96(0.83–1.10)0.0200.96(0.88–1.05)0.244
 Asian2435/6561.02(0.81–1.27)0.2500.97(0.75–1.27)0.3921.23(0.61–2.48)0.5460.99(0.77–1.29)0.300
 Mixed1439/478NANANANA
Source of control
 HB6958/14211.05(0.81–1.37)0.0030.93(0.78–1.12)0.7010.57(0.44–0.75)0.5301.09(0.64–1.85)0.017
 PB53461/51660.97(0.91–1.04)0.4851.00(0.91–1.10)0.2691.08(0.85–1.36)0.0040.91(0.79–1.06)0.885
 BPH3389/4281.22(0.70–2.13)0.0040.95(0.68–1.31)0.4111.22(0.44–3.40)0.3101.12(0.84–1.50)0.116
 Healthy84030/61590.97(0.91–1.03)0.4540.99(0.91–1.08)0.4540.91(0.79–1.05)0.8630.98(0.90–1.06)0.39
Bladder cancer
 Total143553/39551.04(0.93–1.16)0.0091.17(0.99–1.38)0.0050.89(0.74–1.06)0.2681.07(0.98–1.17)0.259
Ethnicity
 Caucasian72512/29121.01(0.90–1.14)0.0851.17(0.92–1.48)0.0010.90(0.66–1.23)0.0331.09(0.93–1.29)0.069
 Asian2551/5751.35(1.15–1.60)0.9410.98(0.76–1.27)0.5990.92(0.38–2.25)0.8931.11(0.91–1.36)0.792
 Mixed2123/1250.75(0.51–1.09)0.2861.00(0.59–1.70)0.5941.04(0.41–2.65)0.4690.78(0.48–1.27)0.258
 African3317/3430.91(0.72–1.14)0.6271.63(1.17–2.25)0.4980.88(0.44–1.75)0.7021.20(0.90–1.59)0.787
Source of control
 HB5813/10131.16(0.90–1.49)0.0241.49(0.96–2.30)0.0021.24(0.84–1.84)0.1371.29(1.09–1.54)0.235
 PB92740/29420.99(0.91–1.07)0.1031.05(0.94–1.17)0.9020.82(0.67–0.99)0.7881.00(0.91–1.11)0.829
Renal cell carcinoma
 Total31138/15631.33(0.90–1.98)0.0001.47(0.81–2.68)0.0001.50(0.86–2.59)0.0411.54(0.82–2.92)0.000
 HWE2970/13911.32(0.72–2.42)0.0001.54(0.59–4.03)0.0001.26(0.74–2.14)0.0801.58(0.58–4.28)0.000
  1. Ph value of Q-test for heterogeneity test, NA not available