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Table 3 Basic characteristics of the included literature (IL-18 -137G/C, 607A/C and CVD risks)

From: No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

Author

year

CVDs type

Sample size

IL-18 -137G/C

PHWE

IL-18 gene -607A/C

PHWE

NOS score

GG

GC

CC

AA

AC

CC

Case

Control

Case/Control

Case/Control

Opstad [16]

2011

CAD

1001

240

532/108

394/82

69/14

0.788

364/74

500/96

132/34

0.762

7

Mitrokhin [17]

2018

CAD

176

116

86/52

76/48

14/12

0.853

56/28

90/66

28/20

0.081

8

Buraczynska [22]

2016

CVD

1103

445

439/214

562/212

102/19

0.002

    

5

Zhang [23]

2011

MI

468

432

352/308

112/116

4/8

0.439

170/90

210/220

88/122

0.616

7

Pei [24]

2009

MI

234

216

180/150

53/63

1/3

0.203

82/42

107/108

45/66

0.854

6

Kariž [25]

2013

MI

169

326

90/162

71/141

8/23

0.301

55/109

86/158

28/59

0.895

7

Rajesh [26]

2015

CAD

300

300

168/176

102/105

30/19

0.533

 

6

Hoseini [27]

2018

CAD

100

100

57/48

39/46

4/6

0.242

 

7

Liu [28]

2009

CAD

241

145

195/99

45/44

1/2

< 0.001

    

6

Jabir [29]

2017

CAD

98

99

48/49

19/16

9/9

< 0.001

65/59

0/2

9/13

< 0.001

6

Omer [30]

2016

PCAD

340

310

217/183

116/108

7/19

0.568

 

6

Deser [31]

2016

PCAD

55

61

36/35

18/22

1/4

0.83

72/46

110/78

55/35

0.72

5

Zhu [32]

2011

CAD

141

240

 

47/51

71/123

23/66

0.653

7

  1. CVDs/CVD cardiovascular diseases, CAD coronary artery disease, MI myocardial infarction, PCAD premature coronary artery
  2. NOS score: Newcastle-Ottawa Scale for Assessing the Quality of Nonrandomized Studies in Meta-Analysis, from 1 to 9