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Table 3 Basic characteristics of the included literature (IL-18 -137G/C, 607A/C and CVD risks)

From: No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

AuthoryearCVDs typeSample sizeIL-18 -137G/CPHWEIL-18 gene -607A/CPHWENOS score
GGGCCCAAACCC
CaseControlCase/ControlCase/Control
Opstad [16]2011CAD1001240532/108394/8269/140.788364/74500/96132/340.7627
Mitrokhin [17]2018CAD17611686/5276/4814/120.85356/2890/6628/200.0818
Buraczynska [22]2016CVD1103445439/214562/212102/190.002    5
Zhang [23]2011MI468432352/308112/1164/80.439170/90210/22088/1220.6167
Pei [24]2009MI234216180/15053/631/30.20382/42107/10845/660.8546
Kariž [25]2013MI16932690/16271/1418/230.30155/10986/15828/590.8957
Rajesh [26]2015CAD300300168/176102/10530/190.533 6
Hoseini [27]2018CAD10010057/4839/464/60.242 7
Liu [28]2009CAD241145195/9945/441/2< 0.001    6
Jabir [29]2017CAD989948/4919/169/9< 0.00165/590/29/13< 0.0016
Omer [30]2016PCAD340310217/183116/1087/190.568 6
Deser [31]2016PCAD556136/3518/221/40.8372/46110/7855/350.725
Zhu [32]2011CAD141240 47/5171/12323/660.6537
  1. CVDs/CVD cardiovascular diseases, CAD coronary artery disease, MI myocardial infarction, PCAD premature coronary artery
  2. NOS score: Newcastle-Ottawa Scale for Assessing the Quality of Nonrandomized Studies in Meta-Analysis, from 1 to 9