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Table 2 Basic characteristics of the included literature (IL 18 genetic variation and IL-18 level)

From: No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

Author

year

Sample size

IL-18 level(pg/ml)-137 G/C

Sample size

IL-18 level(pg/ml)-607 C/A

NOS score

(mean ± SD)

(mean ± SD)

GG

GC

CC

GG

GC

CC

CC

CA

AA

CC

CA

AA

Opstad [16]

2011

532

394

69

248.44 ± 20.54

245.41 ± 20.84

271.43 ± 37.22

364

500

132

243.39 ± 21.02

249.42 ± 20.34

253.33 ± 32.37

7

Mitrokhin [17]

2018

86

76

14

145.40 ± 22.09

94.44 ± 14.32

107.18 ± 23.72

56

90

28

117.08 ± 20.12

86.00 ± 11.58

106.96 ± 20.13

7

  1. NOS score: Newcastle-Ottawa Scale for Assessing the Quality of Nonrandomized Studies in Meta-Analysis, from 1 to 9