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Table 1 Basic characteristics of the included literature (IL-18 level and cardiovascular disease risk)

From: No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

Author

year

CVDs type

Sample size

IL-18level(pg/ml)

male(%)

average age

NOS score

Case

Control

Case

Control

Case

Control

Case

Control

Mallat [18]

2002

MI

42

11

196.50 ± 126.15

48.55 ± 10.670

29 (69.0)

7 (63.6)

62.6 ± 1.9

36.1 ± 4.0

7

Wang [19]

2006

CAD

45

30

373.60 ± 176.70

226.30 ± 88.90

 

5

Jefferis [20]

2013

MI

304

706

418.25 ± 37.80

387.02 ± 131.75

267 (73.4)

512 (72.5)

70.87 ± 5.47

70.83 ± 5.47

7

Blankenberg [21]

2003

CAD

335

670

225.12 ± 4.36

203.91 ± 2.88

 

55.3 ± 0.1

55.2 ± 0.1

7

  1. CVDs/CVD cardiovascular diseases, CAD coronary artery disease, MI myocardial infarction, ACS acute coronary syndrome
  2. NOS score: Newcastle-Ottawa Scale for Assessing the Quality of Nonrandomized Studies in Meta-Analysis, from 1 to 9