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Table 1 Basic characteristics of the included literature (IL-18 level and cardiovascular disease risk)

From: No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

AuthoryearCVDs typeSample sizeIL-18level(pg/ml)male(%)average ageNOS score
CaseControlCaseControlCaseControlCaseControl
Mallat [18]2002MI4211196.50 ± 126.1548.55 ± 10.67029 (69.0)7 (63.6)62.6 ± 1.936.1 ± 4.07
Wang [19]2006CAD4530373.60 ± 176.70226.30 ± 88.90 5
Jefferis [20]2013MI304706418.25 ± 37.80387.02 ± 131.75267 (73.4)512 (72.5)70.87 ± 5.4770.83 ± 5.477
Blankenberg [21]2003CAD335670225.12 ± 4.36203.91 ± 2.88 55.3 ± 0.155.2 ± 0.17
  1. CVDs/CVD cardiovascular diseases, CAD coronary artery disease, MI myocardial infarction, ACS acute coronary syndrome
  2. NOS score: Newcastle-Ottawa Scale for Assessing the Quality of Nonrandomized Studies in Meta-Analysis, from 1 to 9