From: Profiling of the germline mutation BRCA1: p.Ile1845fs in a large cohort of Han Chinese breast cancer
Variables | Carriers | Non-carriers | P |
---|---|---|---|
Age at diagnosis | 0.19 | ||
≤ 50 | 52 | 6943 | |
> 50 | 22 | 4223 | |
na | 20 | 12,221 | |
ER status | 2.21E-08 | ||
Positive | 24 | 11,849 | |
Negative | 44 | 5622 | |
na | 26 | 5916 | |
PR status | 1.29E-06 | ||
Positive | 21 | 10,630 | |
Negative | 46 | 6794 | |
na | 27 | 5963 | |
HER2 status | 0.011 | ||
Positive | 31 | 10,264 | |
Negative | 35 | 6069 | |
na | 28 | 7054 | |
Molecular typing | 3.62E-06 | ||
Luminal-A | 6 | 3726 | |
Luminal-B | 26 | 8061 | |
HER2 overexpression | 12 | 2805 | |
TNBC | 19 | 1743 | |
na | 31 | 7052 | |
Family history | |||
Yes | 35 | 4184 | 0.034 |
No | 41 | 8183 | |
na | 18 | 11,020 | |
Total | 94 | 23,387 | 23,481 |