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Table 2 Clinical characteristics of BRCA1: p.Ile1845fs variant carriers and non-carriers in this study

From: Profiling of the germline mutation BRCA1: p.Ile1845fs in a large cohort of Han Chinese breast cancer

VariablesCarriersNon-carriersP
Age at diagnosis  0.19
  ≤ 50526943 
  > 50224223 
 na2012,221 
ER status  2.21E-08
 Positive2411,849 
 Negative445622 
 na265916 
PR status  1.29E-06
 Positive2110,630 
 Negative466794 
 na275963 
HER2 status  0.011
 Positive3110,264 
 Negative356069 
 na287054 
Molecular typing  3.62E-06
 Luminal-A63726 
 Luminal-B268061 
 HER2 overexpression122805 
 TNBC191743 
 na317052 
Family history
 Yes3541840.034
 No418183 
 na1811,020 
 Total9423,38723,481
  1. Bold: P<0.05