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Table 1 Associations of the single-nucleotide polymorphisms rs2231142 in ABCG2 with the clinical features of the gout patients

From: ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population

Parameter

Baseline (mean ± SEM)

(1)GG

(2)TG

(3)TT

(1)vs.(2)vs.(3) F/x2, P value

Partialη2

Age

52.75 ± 12.88

52.74 ± 13.04

52.95 ± 12.77

52.35 ± 12.97

0.208,0.812

0.000

BMI (kg/m2)

27.16 ± 3.62

27.56 ± 3.58

27.07 ± 3.90

26.89 ± 3.03

2.765,0.063

0.005

SBP (mmHg)

137.53 ± 19.90

138.24 ± 19.21

137.13 ± 19.83

137.53 ± 20.79

0.289,0.749

0.001

DBP (mmHg)

89.48 ± 12.95

89.83 ± 12.62

89.10 ± 13.04

89.87 ± 13.13

0.450,0.638

0.001

FPG (mmol/L)

6.19 ± 1.70

6.18 ± 1.69

6.22 ± 1.77

6.11 ± 1.45

0.435,0.647

0.000

Triglyceride (mmol/L)

2.45 ± 2.20

2.49 ± 2.25

2.41 ± 2.22

2.38 ± 1.56

0.234,0.791

0.001

Total cholesterol (mmol/L)

5.25 ± 1.19

5.29 ± 1.14

5.21 ± 1.23

5.29 ± 1.14

0.641,0.527

0.001

SUA (μmol/L)

474.51 ± 111.37

466.37 ± 115.83*

464.58 ± 112.59*

496.99 ± 104.43

8.798,< 0.001

0.014

Urea nitrogen (mmol/L)

5.81 ± 2.83

5.80 ± 1.92

5.78 ± 3.07

5.93 ± 3.29

0.259,0.771

0.001

SCr (μmol/L)

90.75 ± 42.39

87.18 ± 24.90*

89.13 ± 31.42*

97.74 ± 67.69

5.400,0.005

0.010

  1. Data are the mean ± SEM. Statistical significance was defined as P < 0.05. Partial η2 is effect size. β = 0.2
  2. BMI body mass index, SBP systolic blood pressure. DBP diastolic blood pressure, FPG fasting plasma glucose, SUA serum uric acid, SCr serum creatinine