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Table 1 DEGs were identified from the dataset

From: Integrated identification of key genes and pathways in Alzheimer’s disease via comprehensive bioinformatical analyses

  Gene symbol
Up-regulated genes (hippocampus tissues) ANKIB1 SLC25A46 ZNF621 XIST C1orf87 MAP 3 K19 CD163 LTF AGBL2 PZP TAC1 IGFBP7-AS1 SLC27A6 C1orf192 CD44 SYNE2 FAM216B ABCA6 SPATA18 CCDC11 FAM81B SERPINI2 CRLF1 WDR49 TNFRSF11B DNAAF3 CDK19 RASSF9 FREM3 ANKFN1 ZBBX ART3 CAPS SLC7A11 PIH1D3 WWTR1 CCDC81 EFCAB1 TEX26 EFEMP1 DNAH6 SLC19A3 C21orf62 TDGF1 /// TDGF1P3 MORN5 STON2 CP DYNC2H1 ECM2 WDR96 CXorf30 FANCB CDC14A LEPR /// LEPROT FHL5 ARHGEF7
Down-regulated genes (hippocampus tissues) NWD2 ADAD2 BSN AMPH SLC26A10 NRP1 CYP2A7P1 EBP PCLO ETNK1 SLC24A3 KIT KCNJ6 DDX50 CD300C DIRAS3 RAB3C TTC5 KCNG3 KALRN SCNN1G ACSL4 MICAL2 MAP 7D2 CALY SOX1 C16orf74 DNASE1L2 NEFH ANK1 COL2A1 LOC100132891 RCOR3 GABRG2 SPDEF ACHE RDH10 TRAF3IP1 CNR1 TMEM35 PDPN F12 KCNC1 OBSCN STC2 EXOSC3 ACTRT3 RHCG DGAT2 SLC35G1 CAMK1 KCNK10 DCAF15 METTL10 GLS2 FHL2 MICB MCHR1 PPM1E TP53I11 KCMF1 CELF4 SCG2 SCN2B VAPA CARTPT NRP2 CDC42 MIR22 /// MIR22HG BRSK2 SPANXA1 /// SPANXA2 /// SPANXB1 /// SPANXC ATP1A3 SLC2A3 PLK2 HOMER2 GFOD1 NCDN GLRX PCOLCE2 MATN1 NFKBID LAMP5 LY86-AS1 RPL27A /// SNORA45A SYN2 KCNA1 KCNJ5 GSDMB SLC6A3 CADPS ATP8A2 SRGAP3 NUP93 TMEM155 QRICH1 IL4I1 DHRS2 AFF2 KISS1R STRIP2 TRPV2 SGPP2 OPRK1 SLC22A8 SSTR2 SLC1A6 C14orf180 RIMKLA KLK7 RET NKX2–5 ACTN1 SPAG11A LEPREL2 IGFBPL1 FABP3 MAGEL2 PPP1R17 IL12RB1 SYT2 SNORD114–3 AFF3 PCDH20 LRRFIP1 LINC00622 L3MBTL1 PYCRL TBC1D26 /// ZNF286A ATF7IP2 PWP2 CACNA1A KCNJ4 TRHDE SUSD4 UBASH3B SIAH1 PTH2R SDK1 CCNJL KCNQ5 TMEM61 PML NRIP3 METTL7B LINC00282 WIPF3 CLSTN2 GREM2 LOC389906 IFRD1 MRAP2 CENPVP1 /// CENPVP2 KCNIP2 KDM6B CTSG KMT2D CPNE4 PGM5 CARD14 CST7 SPOCD1 HINT3 NR4A3 CENPW VEGFA PCDH8 PKIB DNAJB5 ARC GRP CKS2 PTGS1 ARHGAP36 A1BG RTF1 AQP3 TSPAN18 TH CHGB CITED1 CALB1 CRABP1 MIR7-3HG PDYN FNDC9 SCGN WFIKKN2 BDNF RAE1 INHBA EGR4 FOSB LAMB3 EGR2 MPO NPAS4
Up-regulated genes (entorhinal cortex tissues) ANKIB1 TAC1 SLC25A46 XIST ZNF621 C1orf192 SPATA13 PKP2 CDK19 A2ML1 CX3CR1 C1orf87 RAPGEF5 CD24 ID2 /// ID2B DST
Down-regulated genes (entorhinal cortex tissues) RIT2 SLC17A6 POPDC3 RPLP2P1 /// RPLP2P1 NEFH CKS2 LRRFIP1 CYP27C1 CABP1 SCGB3A1 LY86-AS1 VASH2 QPCT CENPF MPP7 TWIST2 COL4A1 TCERG1L RGS2 HSPB3 ANKRD34C OTP KDELR3 TPSAB1 BRE-AS1 CARTPT SECTM1 XIRP1 IL1RL1 GPR68 MMP10 TPSB2 DUSP2 RSPO2 PTGS2 RTF1 IL7R GPR3 FOSL1 LINC00622 IL11 DHRS2 FOSB CBLN1 SAA1 /// SAA2 C2CD4A SPOCD1 TGFBI HDC HS3ST2 LINC00960 ATP1B4 RAE1 PMCH LAMB3 OXT INHBA AVP
  1. 56 up-regulated genes and 195 down-regulated genes were included in the hippocampus tissues of AD patients’ samples compared to normal hippocampus tissues; meanwhile, 16 up-regulated genes and 58 down-regulated genes were included in the entorhinal cortex tissues of AD patients’ samples compared to normal entorhinal cortex tissues. (The up-regulated genes were listed from the largest to the smallest of fold changes, and down-regulated genes were listed from the smallest to largest of fold changes)