Table 1 Top 3 the most significantly enriched KEGG pathways of up and down regulated DEGs respectively
From: Differentially expressed genes between systemic sclerosis and rheumatoid arthritis
Regulate | Term | Count | P-value | Genes | Fold Enrichment |
|---|---|---|---|---|---|
up | hsa04512:ECM-receptor interaction | 16 | 4.35E-06 | COL4A4, ITGA1, ITGA2, ITGA10, CHAD, LAMA2, CD36, COMP, RELN, TNN, THBS1, LAMB1, COL24A1, THBS2, COL11A1, THBS4 | 4.194075 |
up | hsa04310:Wnt signaling pathway | 19 | 2.80E-05 | VANGL2, MMP7, PPP3R1, FZD7, FZD6, CTNNB1, WNT2, GPC4, PLCB4, EP300, DKK1, PRICKLE1, SFRP2, JUN, SFRP4, PRICKLE2, WNT9A, SOX17, BAMBI | 3.139857 |
up | hsa04350:TGF-beta signaling pathway | 14 | 6.24E-05 | BMP4, BMP2, FST, BMPR2, SMAD1, ACVR1C, INHBA, EP300, ID1, BAMBI, THBS1, BMPR1B, BMP5, ACVR1 | 3.80088 |
down | hsa05340:Primary immunodeficiency | 6 | 3.89E-07 | CD19, CD3D, CD8A, IL2RG, CD79A, IL7R | 36.95187 |
down | hsa04640:Hematopoietic cell lineage | 7 | 2.03E-06 | CD19, CD3D, CD8A, MS4A1, CD2, IL7R, CSF1R | 17.24421 |
down | hsa04060:Cytokine-cytokine receptor interaction | 6 | 0.003777 | CXCL13, IL21R, TNFRSF17, IL2RG, IL7R, CSF1R | 5.462451 |