Fig. 7

Drosophila Limpet is a homolog of human KyoT2. D. melanogaster Limpet protein harbors a PET domain, followed by six LIM domains. The alignment with human KyoT2 (also named Fhl1C) reveals surprising similarity between the LIM domains of KyoT2 (black labelling) and LIM domains two to four of Drosophila Limpet (isoform PN, red labelling). Intriguingly, three identical intron positions are present within this region (red arrows). Black arrows mark intron positions specific to Limpet. The CSL binding domain of KyoT2 (CID, italics) is not present in Limpet at a corresponding position. A similar tetra-peptide motif TWVP (italic green), however, is located at the N-terminus of the PET domain. Red residues are identical between the two proteins, blue are not conserved, black absent in one of the two species