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Fig. 6 | Hereditas

Fig. 6

From: The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis

Fig. 6

Alignment of KyoT2 homologues from vertebrates. a Only placental mammals contain a KyoT2 protein with conserved CSL binding motif (ΦWΦP, cyan). Already in marsupial (koala P. cinereus and opossum M. domestica) or birds (eagle H. leudocephalus and tit P. major) the motif is changed, but an open reading frame still remains. In fish, a stop codon (*) occurs exactly within the motif, however, sequences C-terminally translate into many conserved residues (grey) compared to mammals. All proteins consist of two and a half LIM domains (red lines), each containing two tandemly repeated zinc fingers. Asterisks indicate zinc binding residues. Blue are identical, red are highly conserved and yellow are related residues. Note changes in marsupials. b Alignment of mouse KyoT2 with marsupial koala and opossum. Note high overall conservation. The ΦWΦP tetra-peptide motif is highlighted

Placental mammals (black box): Hs: Homo sapiens (man), Mm: Mus musculus (mouse), Cl: Canis lupus (wolf), Fc: Felis catus (cat), Lv: Lipotes vexillifer (chinese river dolphin); Marsupials (grey box): Pc: Phascolarctos cinereus (koala), Md: Monodelphis domestica (opossum). Birds (blue box): Hl: Haliaeetus leucocephalus (bald eagle), Pm: Parus major (great tit). Fish (green box): Dr.: Danio rerio (zebrafish), Ss: Salmon solar (atlantic salmon), Ch: Clupea harengus (herring). Reptiles (brown box): Am: Alligator mississippiensis.

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