Fig. 4

Comparison of SHARP/MINT proteins in vertebrates. Comparison of SHARP/MINT orthologues in vertebrates; shown is the alignment of the RBP-ID and C-terminally adjacent amino acids. Identical residues are marked in blue identical, highly conserved in red, conserved in yellow. a Alignment over the whole vertebrate tree, b) alignment of mammals, c) alignment of birds and reptiles, d) alignment of fish, e) alignment of zebra fish with chondrichthyes (cartilaginous fish) and coelacanth. Human RBP-ID, shown to interact with CSL BTD and CSL CTD, is highly conserved in all vertebrates except the arctic lamprey, where it ends a bit short. Also C-terminally adjacent sequences except of lamprey (italic) are conserved, which becomes apparent in the comparison of the group specific alignments. The rattlesnake, however, is distinctly different from alligator and birds in this region. Mammals: Hs: Homo sapiens (man), Bt: Bos taurus (cattle), Lv: Lipotes vexillifer (chinese river dolphin), Mj: Manis javanica (malayan pangolin), Pman: Peromyscus maniculatus (great tit), Eed: Elephantulus edwardii (cape elephant shrew), Eeu: Erinaceus europaeus (european hedgehog), Reptile and birds: Am: Alligator mississippiensis (alligator), Za: Zonotrichia albicollis (sparrow), Pmaj: Parus major (great tit), Hl: Haliaeetus leucocephalus (bald eagle), Ch: Crotalus horridus (timber rattlesnake), Fish: Dr.: Danio rerio (zebrafish), Aa: Anguilla Anguilla (eel), Gm: Gadus morhua (ghostshark), Ok: Oncorhynchus kisutch (coho salmon), Le: Leucoraja erinacea (little skate), Cm: Callorhinchus milii (ghostshark), Lca: Lethenteron camtschaticum (lamprey), Lch: Latimeria chalumnae (coelacanth)

See also Additional file 3 Dataset 2 for common names