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Table 1 The ten most significantly up- and down-regulated genes in this study

From: Microarray study of gene expression profile to identify new candidate genes involved in the molecular mechanism of leptin-induced knee joint osteoarthritis in rat

Accession number

Gene symbol

Description

Fold change

Ten most significantly up-regulated genes

 NM_001106767

ELANE

Rattus norvegicus elastase, neutrophil expressed

68.85

 NM_001106041

CTSG

Rattus norvegicus cathepsin G

58.80

 NM_023022

RHAG

Rattus norvegicus Rh-associated glycoprotein

49.08

 CA507495

S100A8

Rattus norvegicus S100 calcium binding protein A8

42.58

 XM_003748860

SAAL1

Rattus norvegicus serum amyloid A-like 1

41.35

 NM_173299

NP4

Rattus norvegicus defensin NP-4 precursor

35.68

 NM_020074

SRGN

Rattus norvegicus serglycin

32.10

 NM_133540

NKG7

Rattus norvegicus natural killer cell group 7 sequence

31.23

 NM_001024264

PRTN3

Rattus norvegicus proteinase 3

28.58

 NM_053587

S100A9

Rattus norvegicus S100 calcium binding protein

27.46

Ten most significantly down-regulated genes

 NM_001108377

PCK2

Rattus norvegicus phosphoenolpyruvate carboxykinase 2

−52.82

 NM_053676

MTNR1A

Rattus norvegicus melatonin receptor 1A

−34.16

 NM_001000762

OLR322

Rattus norvegicus olfactory receptor 322

−26.07

 NM_001013937

ACTRT2

Rattus norvegicus actin-related protein T2

−20.12

 NM_001025422

IRAK2

Rattus norvegicus interleukin-1 receptor-associated kinase

−16.18

 NM_012508

ATP2B2

Rattus norvegicus ATPase, Ca++ transporting, plasma membrane 2

−13.46

 NM_001271377

PCDH15

Rattus norvegicus protocadherin 15

−10.49

 NM_001000595

OLR1230

Rattus norvegicus olfactory receptor 1230

−10.24

 NM_012926

CD80

Rattus norvegicus Cd80 molecule

−7.81

 NM_001106657

ZBTB5

Rattus norvegicus zinc finger and BTB domain containing 5

−7.70