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Table 1 A summary of candidate genes of human adaptation on pigmentation

From: Adaptation of human skin color in various populations

Gene SNP Population Skin color Hair color Eye color References
APBA2 rs4424881    [68]
ASIP rs6058017   [71, 72, 74, 118]
rs4911442   [40, 118]
DCT rs1325611    [49]
rs1407995    [40, 49, 74]
rs9516418    [49]
rs3782974    [50]
rs2031526    [38]
GRM5 rs10831469    [68]
HERC2 rs79097182    [60]
IRF4 rs12203592   [40, 118]
rs1540771    [60, 118]
KITLG rs1881227    [56, 119]
rs642742    [61, 118]
rs12821256    [40, 60, 118]
MC1R rs885479   [40, 74, 118, 119]
rs1805005   [29, 74, 118, 120]
rs1805006   [74, 118]
rs1805007   [57, 74, 118, 121]
rs1805008   [57, 74, 118]
rs1805009    [118]
rs2228479   [74, 107, 118]
rs2353688    [60]
rs146972365    [60]
rs8063160    [60]
rs11547464   [118]
rs1110400   [118]
OCA2 rs12913832   [23, 40, 68, 118]
rs1800404    [48]
rs1800407   [118]
rs1800414   [40, 47, 50, 118, 122]
rs74653330    [40, 48]
rs150335311    [48]
rs1448484    [50]
rs1667394    [57]
SLC24A4 rs12896399 [57, 118]
rs8014907    [60]
SLC24A5 rs1426654    [17, 23, 40, 61, 68, 72, 75, 118]
rs2470102   [68]
SLC45A2 rs16891982    [17, 18, 21, 23, 27, 40, 50, 61, 112, 118]
rs26722    [18, 27, 118]
rs11568737    [48]
rs35395    [68]
TPCN2 rs72930659    [60]
rs35264875    [118]
rs3829241    [118]
TYR rs1042602    [40, 57, 68, 118]
rs1393350    [57]
rs13312741    [48]
rs10831469    [68]
rs1126809    [40, 118]
rs1800422    [118]
TYRP1 rs2733832   [49, 118]
rs2733831    [61]
rs10809814    [49]
rs2762464    [50]
rs1408799   [40, 118]
  1. The derived allele is associated with pigmentation in European populations
  2. The derived allele is associated with pigmentation in East Asian populations