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Table 1 Alleles, genotypes and haplotypes frequencies of LEPR SNPs in a Co-dominant model

From: Leptin receptor gene polymorphisms and morbid obesity in Mexican patients

 

Patients (n = 28)

Controls (n = 56)

p valuea

OR (95 % CI)b

Alleles

 rs1137100-C (Lys109Arg)

0.45

0.43

0.99

1.08 (0.51–2.30)

 rs1137100-T

0.55

0.57

0.99

0.92 (0.43–1.96)

 rs1137101-G (Gln223Arg)

0.43

0.39

0.79

1.18 (0.58–2.39)

 rs1137101-A

0.57

0.61

0.79

0.85 (0.41–1.72)

rs1805134 - C (Ser343Ser) c

0.17

0.06

0.02

3.41 (1.11–10.49)

 rs1805134-T

0.83

0.94

0.02

0.29 (0.09–0.90)

 Ser492Thr-G

1

1

 Ser492Thr-C

0

0

 rs1805094-G (Lys656Asn)

0.22

0.12

0.13

2.02 (0.89–4.59)

 rs1805094-C

0.78

0.88

0.13

0.49 (0.22–1.13)

 rs1805096-G (Pro1019Pro)

0.40

0.40

0.93

0.97 (0.48–1.95)

 rs1805096-A

0.60

0.60

0.93

1.03 (0.51–2.07)

Genotypes

 rs1137100 C/C

0.05

0.10

0.87

0.66 (0.07–6.01)

 rs1137100 C/T

0.79

0.65

0.42

1.85 (0.19–0.59)

 rs1137100 T/T

0.16

0.25

0.65

0.64 (0.16–2.57)

 rs1137101 A/A

0.32

0.30

0.88

1.09 (0.38–3.16)

 rs1137101 A/G

0.50

0.61

0.54

0.65 (0.24–1.76)

 rs1137101 G/G

0.18

0.09

0.45

2.28 (0.55–9.43)

rs1805134 T/T d

0.65

0.89

0.03

0.24 (0.07–0.83)

rs1805134 T/C d

0.35

0.11

0.03

4.01 (1.20–13.41)

 Ser492Thr G/G

1.00

1.00

 rs1805094 C/C

0.59

0.77

0.13

0.43 (0.17–1.13)

 rs1805094 C/G

0.38

0.22

0.17

2.19 (0.83–5.77)

 rs1805094 G/G

0.03

0.01

0.82

2.09 (0.13–34.61)

 rs1805096 A/A

0.33

0.33

0.84

1.05 (0.37–2.92)

 rs1805096 A/G

0.54

0.54

0.82

1.01 (0.38–2.66)

 rs1805096 G/G

0.13

0.13

0.80

0.99 (0.23–4.20)

Haplotypese

 CGTGCA

0.266

0.271

0.94

0.97 (0.47–2.01)

 TATGCG

0.173

0.223

0.47

0.74 (0.32–1.69)

 TATGCA

0.108

0.106

0.98

1.01 (0.36–2.88)

 CATGCG

0.078

0.117

0.44

0.64 (0.20–2.00)

 TATGGA

0.084

0.088

0.92

0.94 (0.30–3.01)

 TGCGCA

0.073

0.058

0.70

1.28 (0.36–4.62)

 CATGCA

0.037

0.041

0.91

0.91 (0.17–4.92)

 TGTGCG

0.037

0.029

0.79

1.27 (0.22–7.53)

 TATGGG

0.047

0.024

0.39

2.12 (0.37–12.03)

 TACGGG

0.032

0.005

0.13

7.97 (0.34–185.4)

 TGTGCA

0.005

0.016

0.56

0.34 (0.01–15.99)

  1. * p value with Yates correction; bOdds ratio (95 % confidence interval); cStatistical power = 0.632; dStatistical power = 0.679; e LEPR haplotypes: rs1137100-rs1137101-rs1805134-Ser492Thr-rs1805094-rs1805096. Characters in bold and italics indicate statistically significant values