From: Leptin receptor gene polymorphisms and morbid obesity in Mexican patients
Patients (n = 28) | Controls (n = 56) | p valuea | OR (95 % CI)b | |
---|---|---|---|---|
Alleles | ||||
rs1137100-C (Lys109Arg) | 0.45 | 0.43 | 0.99 | 1.08 (0.51–2.30) |
rs1137100-T | 0.55 | 0.57 | 0.99 | 0.92 (0.43–1.96) |
rs1137101-G (Gln223Arg) | 0.43 | 0.39 | 0.79 | 1.18 (0.58–2.39) |
rs1137101-A | 0.57 | 0.61 | 0.79 | 0.85 (0.41–1.72) |
rs1805134 - C (Ser343Ser) c | 0.17 | 0.06 | 0.02 | 3.41 (1.11–10.49) |
rs1805134-T | 0.83 | 0.94 | 0.02 | 0.29 (0.09–0.90) |
Ser492Thr-G | 1 | 1 | – | – |
Ser492Thr-C | 0 | 0 | – | – |
rs1805094-G (Lys656Asn) | 0.22 | 0.12 | 0.13 | 2.02 (0.89–4.59) |
rs1805094-C | 0.78 | 0.88 | 0.13 | 0.49 (0.22–1.13) |
rs1805096-G (Pro1019Pro) | 0.40 | 0.40 | 0.93 | 0.97 (0.48–1.95) |
rs1805096-A | 0.60 | 0.60 | 0.93 | 1.03 (0.51–2.07) |
Genotypes | ||||
rs1137100 C/C | 0.05 | 0.10 | 0.87 | 0.66 (0.07–6.01) |
rs1137100 C/T | 0.79 | 0.65 | 0.42 | 1.85 (0.19–0.59) |
rs1137100 T/T | 0.16 | 0.25 | 0.65 | 0.64 (0.16–2.57) |
rs1137101 A/A | 0.32 | 0.30 | 0.88 | 1.09 (0.38–3.16) |
rs1137101 A/G | 0.50 | 0.61 | 0.54 | 0.65 (0.24–1.76) |
rs1137101 G/G | 0.18 | 0.09 | 0.45 | 2.28 (0.55–9.43) |
rs1805134 T/T d | 0.65 | 0.89 | 0.03 | 0.24 (0.07–0.83) |
rs1805134 T/C d | 0.35 | 0.11 | 0.03 | 4.01 (1.20–13.41) |
Ser492Thr G/G | 1.00 | 1.00 | – | – |
rs1805094 C/C | 0.59 | 0.77 | 0.13 | 0.43 (0.17–1.13) |
rs1805094 C/G | 0.38 | 0.22 | 0.17 | 2.19 (0.83–5.77) |
rs1805094 G/G | 0.03 | 0.01 | 0.82 | 2.09 (0.13–34.61) |
rs1805096 A/A | 0.33 | 0.33 | 0.84 | 1.05 (0.37–2.92) |
rs1805096 A/G | 0.54 | 0.54 | 0.82 | 1.01 (0.38–2.66) |
rs1805096 G/G | 0.13 | 0.13 | 0.80 | 0.99 (0.23–4.20) |
Haplotypese | ||||
CGTGCA | 0.266 | 0.271 | 0.94 | 0.97 (0.47–2.01) |
TATGCG | 0.173 | 0.223 | 0.47 | 0.74 (0.32–1.69) |
TATGCA | 0.108 | 0.106 | 0.98 | 1.01 (0.36–2.88) |
CATGCG | 0.078 | 0.117 | 0.44 | 0.64 (0.20–2.00) |
TATGGA | 0.084 | 0.088 | 0.92 | 0.94 (0.30–3.01) |
TGCGCA | 0.073 | 0.058 | 0.70 | 1.28 (0.36–4.62) |
CATGCA | 0.037 | 0.041 | 0.91 | 0.91 (0.17–4.92) |
TGTGCG | 0.037 | 0.029 | 0.79 | 1.27 (0.22–7.53) |
TATGGG | 0.047 | 0.024 | 0.39 | 2.12 (0.37–12.03) |
TACGGG | 0.032 | 0.005 | 0.13 | 7.97 (0.34–185.4) |
TGTGCA | 0.005 | 0.016 | 0.56 | 0.34 (0.01–15.99) |