The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis

Ruiz-Ramos, David; Hernández-Díaz, Yazmín; Tovilla-Zárate, Carlos Alfonso; Juárez-Rojop, Isela; López-Narváez, María Lilia; González-Castro, Thelma Beatriz; Torres-Hernández, Manuel Eduardo; Baños-González, Manuel Alfonso

doi:10.1186/s41065-015-0004-7

Hereditas

Table 2 Genotype and allele distribution in association studies on the Trp719Arg polymorphism of the KIF6 gene with CHD

From: The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis

Author	Genotype cases			Genotype controls			Allele cases		Allele controls		HWE
	Trp/Trp	Trp/Arg	Arg/Arg	Trp/Trp	Trp/Arg	Arg/Arg	Trp	Arg	Trp	Arg	Cases p value	Controls p value
Berglund, G. [17]	35	38	13	33	54	12	108	64	120	78	0.64	0.20
Vartiainen, E. [18]	64	81	22	73	76	23	209	125	222	122	0.74	0.62
Senti, M. [19]	134	139	39	141	137	39	407	217	419	215	0.80	0.53
Yusuf, S. [20]	351	498	243	389	531	267	1200	984	1309	1065	0.09	0.06
Low, A. F. [21]	89	86	29	114	111	35	264	144	339	181	0.53	0.34
Helgadottir, A. [22]	370	399	106	174	221	52	1139	611	569	325	0.94	0.18
Helgadottir, A. [22]	359	441	133	194	213	61	1159	707	601	335	0.59	0.84
Samani, N. J. [23]	447	529	150	522	593	162	1423	829	1637	917	0.79	0.80
Samani, N. J. [23]	293	328	101	662	753	228	914	530	2077	1209	0.57	0.55
Meng, W. [24]	203	226	53	261	292	69	632	332	814	430	0.42	0.37
Iakoubova, O. [14]	104	137	35	256	204	59	345	207	716	322	0.36	0.06
Meiner, V. [25]	187	228	90	216	260	83	602	408	692	426	0.16	0.78
Serre, D. [26]	335	337	117	354	402	103	1007	571	1110	608	0.03*	0.55
Morgan, T. M. [27]	322	377	108	256	304	77	1021	593	816	458	0.93	0.39
Assimes, T. L. [28]	162	187	83	144	183	130	511	353	471	443	0.03*	0.00*
Vennemann, M. M. [29]	311	379	103	430	528	163	1001	585	1388	854	0.44	1.00
Sutton, B. S. [30]	545	570	183	297	347	86	1660	936	941	519	0.09	0.33
Martinelli, W. [31]	437	501	168	145	191	47	1375	837	481	285	0.22	0.22
Herrera-Galeano, J. E. [32]	106	148	31	626	752	201	360	210	2004	1154	0.05	0.30
Stewart, A. F. [33]	183	695	662	205	616	634	1061	2019	1026	1884	1.00	0.00*
Luke, M. M. [34]	73	254	178	102	373	307	400	610	577	987	0.26	0.53
Bare, L. A. [13]	785	952	250	896	966	285	2522	1452	2758	1536	0.13	0.33
Wu, G. [16]	104	164	88	168	268	132	372	340	604	532	0.16	0.20
Wu, G. [16]	16	68	30	168	268	132	100	128	604	532	0.03*	0.20
Peng, P. [14]	69	149	71	139	262	121	287	291	540	504	0.63	0.93
Wu, G. [35]	74	141	73	101	166	79	289	287	368	324	0.72	0.51

*p value: statistical significance

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ISSN: 1601-5223

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