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Fig. 11 | Hereditas

Fig. 11

From: Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment

Fig. 11

In auditory cells (HEI-OC1) cells, NRF2, HO-1 and NQO1 were up-regulated after cisplatin injury, but NRF2, HO-1 and NQO1 was obviously up-regulated after RG108 + CIS treatment. A Western blotting was used to detect NRF2 protein levels in HEI-OC1 cells treated with DMSO, CIS, CIS + RG108, RG108. A Use ImageJ to analyze the relative expression of NRF2 protein. Data are expressed as mean ± SD, n = 3,* P < 0.05 compared with the control group;##P < 0.01, compared with cisplatin group. B Western blotting was used to detect HO-1 and NQO1 protein levels in HEI-OC1 cells treated with DMSO, CIS, CIS + RG108, RG108. C Use ImageJ to analyze the relative expression of HO-1 protein. Data are expressed as mean ± SD, n = 3,* P < 0.05 compared with the control group;##P < 0.01, compared with cisplatin group. D Use ImageJ to analyze the relative expression of NQO1 protein. Data are expressed as mean ± SD, n = 3,* P < 0.05 compared with the control group;##P < 0.01, compared with cisplatin group

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Hereditas

ISSN: 1601-5223

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